9:25 am Chair’s Opening Remarks
Highlighting the Opportunities for the Development of Novel Clinically Effective Biomarkers that Align with the Heterogenous Nature of Age-Related Disease
9:30 am Coming of Age: Data to Drugs, Diagnostics, Disease Detection & Delaying Death
Synopsis
- Leveraging molecular networks and intermediate phenotypes to combat aging
- Translating spatial and longitudinal multiomics, anchored in genomics, into a pre-clinical and clinical pipeline
- Applying highly integrated multiomic biological big data in individuals, providing a roadmap for a longer, healthier life
10:00 am The Hunt for Senescence Cells in vivo
Synopsis
- Advancing knowledge about the nature of cells with senescent biomarkers in vivo (revisiting the main postulates of the senescence cell hypothesis)
- Is extrinsic genotoxic stress translated into accelerated aging?
- Does SASP depend on DNA damage?
10:30 am Panel Discussion: What Do We Follow as a Biomarker to Ensure Clinical Trial Success?
Synopsis
- Does positive biomarker engagement also suggest patient benefit?
- Unlocking the potential of predictive biomarkers for disease and indications of aging process
- Using less invasive methods for seeing inside the body
11:00 am Morning Break & Networking
Reimagining Age-Related Disease Therapeutics by Unravelling the Most Cutting-Edge Advancements Towards Clinical Success
11:30 am A Stem Cell-Derived Secretome Targeting Age-Acquired Immune Decline
Synopsis
- Discussing the association of aging and a decline in secretory factors that benefit immune system development, modulation and health
- Describing the novel method of growing human stem cells for clinical use and directing them to produce a secretome (STEM)
- Revealing an FDA-approved Phase 1/2a human clinical trial to test the safety and efficacy of STEM in elderly patients with muscle atrophy related to knee osteoarthritis
12:00 pm Mapping Secreted Proteins to Unmet Medical Needs by Mining the Regenerative Secretomes of Human Pluripotent Stem Cells
Synopsis
- Secreted proteins are an underleveraged class of biologics with proven therapeutic potential
- Exhibiting the discovery that human pluripotent stem cell secretomes are enriched with secreted proteins containing regenerative potency
- The creation of a map of regenerative protein biology with a compounding database of protein ligand-receptor interactions and disease-modifying phenotypes induced in various aged and diseased tissue types
- This JuvNET knowledge base is enabling a computationally driven platform for systematic biologics drug discovery and development
12:30 pm Lunch Break & Networking
1:30 pm Detailing Novel Strategies in Leveraging Space Studies & Human Organoids to Accelerate Aging & Run More Efficient Trials
Synopsis
- Strategically leveraging astronaut data to effectively study the acceleration of age-related diseases
- Moving towards an ultimate model of aging for age related diseases from cardiovascular aging to neurocognitive impairment
- All in human research scheme to ensure high translational ability and high efficacy in clinical trials
Shifting the Paradigm: Extending Lifespan vs Improving Health Span
2:00 pm Panel Discussion: Strengthening the Synergy Between Pharma & Biotech
Synopsis
- What are the diseases to focus on for healthy aging?
- How could pharma and biotech work together more effectively within this space?
2:30 pm Afternoon Break & Networking
3:00 pm Redefining the Space: Diving Deeper into the Potential & Perceived Added Therapeutic & Market Value for Personalized Medicine that Promote Healthy Aging
Synopsis
- Identifying the recent advances and challenges of personalised medicine to treat age-related disease
- How can we unlock the potential of personalized medicine to improve patient outcomes and reduce healthcare costs?
Summarising the Evidence Suggesting Social Challenges Exacerbate Age-Related Disease
3:30 pm Uncovering the Connection Between Aging & Alzheimer’s Disease & Exploring the Genetic Variants Involved
Synopsis
- What is the molecular connection between brain aging and Alzheimer’s disease
- What is the role of diet and carbohydrate metabolism in influencing Alzheimer’s disease
- How can we leverage model organism research to determine conserved mechanisms that influence neurodegeneration and identify therapeutics for treating dementia
4:00 pm Chair’s Closing Remarks
