Conference Day Two

8:00 am Check-In & Coffee

8:50 am Chair’s Opening Remarks

Unlocking Precision Medicine: Leveraging Bioinformatics and Multiomics for Targeted Solutions to Age-Related Diseases

9:00 am Harnessing Transcriptomics for Precision Age-Related Therapeutics

  • Shan Jiang Senior Scientific Lead, Discovery Bioinformatics, Loxo@Lilly

Synopsis

  • Analysing genomics data for oncology targets
  • Developing computational approaches for large-scale genomics data
  • Applying large scale genomic data to age-related disease targets

9:30 am Exploring Functional Genomics for Precision Age-Related Therapeutics

Synopsis

  • Analysing gene expression pathways to understand how transcriptomic data can illuminate process implicated in aging
  • Exploring the use of transcriptomics in biomarker identification to gain insights into the molecular signatures of age-related diseases
  • Examining the temporal dynamics of gene expression changes during aging

10:00 am Leveraging AI to Identify Cellular Senescence Heterogeneity Across AgeRelated Diseases for therapeutic Interventions

Synopsis

  • Senolytics are a powerful therapeutic opportunity to treat age-related chronic conditions
  • An analogy with cancer cells: Cellular senescence is pleiotropic and characterised by a high degree of heterogeneity
  • Not all states of cellular senescence are relevant therapeutic targets
  • Introducing Alembic: AI computational single-cell multi-omics platform developed to elucidate the heterogeneity between cell types and cell states for novel first-in-class drug discovery

10:30 am Morning Break & Networking

11:00 am An Overview of the Epigenetic Mechanisms of Aging

  • Payel Sen Stadtman tenure-track investigator, National Institute of Aging

Synopsis

  • Understanding the fundamental concepts underlying aging at the epigenetic level
  • Explore the potential of epigenetic interventions as novel strategies for extending health span and lifespan
  • Explore the role of DNA methylation, histone modifications, and non-coding RNAs in regulating the aging process

Securing Funding and Partnerships in a New and Growing Field

11:30 am Panel Discussion – Securing Partnerships in the Age-Related Therapeutics Space

  • Peng Leong Chief Business Officer, BioAge
  • Yuxi Lin Senior Director - Venture Science, Eli Lilly & Co.

Synopsis

  • Discussing strategies to get investors and big pharma comfortable with the concept of an emerging field
  • Tackling the complexities of Intellectual Property ownership when forming partnerships and collaborations
  • Why is now the right time to form a collaboration?

12:30 pm Lunch

Studying Biological Clocks for Therapeutic Breakthroughs

1:30 pm Adropin: a circadian neuropeptide and potentially modifiable risk indicator of aging-related cognitive decline

  • Andrew Butler Professor, Department of Pharmacology & Physiology, Institute for Translational Neuroscience, Saint Louis University School of Medicine

Synopsis

  • Identified a small, secreted peptide highly expressed in the human nervous system. Expression profiling indicates a circadian pattern and positive relationships with gene networks involved in mitochondrial and synaptic functions
  • Expression in the brain declines with aging; in humans low circulating levels predict increased risk of cognitive decline in community-dwelling adults aged >70 years
  • Preclinical studies using mouse models indicate increasing levels can reverse aging-related cognitive decline

2:00 pm Rewinding Molecular Aging Clocks Through Telomere Extension

  • Suzana Tulac Director - Translational Development and Project Management, Rejuvenation Biotech

Synopsis

  • Increasing telomere length to extend human health span
  • Using mRNA encoding telomerase reverse transcriptase to lengthen telomeres
  • Leveraging this technology to treat IPF

2:30 pm Panel discussion: A Deep-Dive Into Biological Clocks for Therapeutics Breakthroughs

Synopsis

  • Leveraging biological clocks in the development of age-related therapeutics
  • Using tissue-specific biological clocks to develop interventions that target systemic aging
  • Deciphering whether alterations in biological clocks directly contribute to aging

3:30 pm Chair’s Closing Remarks

3:40 pm End of Conference Day 2