Adropin: a circadian neuropeptide and potentially modifiable risk indicator of aging-related cognitive decline
Time: 1:30 pm
day: Conference Day Two
Details:
- Identified a small, secreted peptide highly expressed in the human nervous system. Expression profiling indicates a circadian pattern and positive relationships with gene networks involved in mitochondrial and synaptic functions
- Expression in the brain declines with aging; in humans low circulating levels predict increased risk of cognitive decline in community-dwelling adults aged >70 years
- Preclinical studies using mouse models indicate increasing levels can reverse aging-related cognitive decline
