7:30 am Check-In & Coffee
8:20 am Chair’s Opening Remarks
Identifying Biomarkers of Aging for Early Detection and Appropriate Clinical Endpoints
8:30 am Advancing Biomarker Detection and Identification for Neurodegenerative Indications
Synopsis
- Using AI and machine learning to track brain aging
- Maximising personal data-driven techniques to track biomarkers earlier in life
- Moving towards preventative therapeutics for neurodegeneration rather than a reactive approach
9:00 am Novel Techniques to Identify Biomarkers in Age-Related Conditions
Synopsis
- Addressing the challenges in addressing low abundance proteins that can be important markers of aging
- Accurately following epigenetic and DNA methylation markers
- Standardizing biomarker techniques across the field
9:30 am Panel Discussion: Leveraging Novel Technology for Identifying Biomarkers of Aging
Synopsis
- Understanding how biomarkers can detect subtle changes as molecular and cellular levels before symptoms emerge
- Discussing the role of biomarkers in precision medicine that address the unique aging process of individuals
- Outlining the use of epigenetic clocks and advanced imaging techniques to discover novel biomarkers
10:30 am Morning Refreshments & Speed Networking Session
Synopsis
This session is the ideal opportunity to get face-to-face time with many of the brightest minds working in the age-related therapeutics field and establish meaningful business relationships to pursue for the rest of the conference.
Exploring the Latest Breakthroughs in Novel Technology Targeting the Hallmarks of Aging
11:30 am The Opportunity for Non-Diluted Funding to Small Biotechs from the National Institute on Aging
Synopsis
- Introduction to SBIR and STTR programs
- Comercializing products addressing aging & aging-related diseases and conditions
11:45 am mRNA-Mediated Epigenetic Reprogramming of Aging: A Safe and New Paradigm in Personalized Regenerative Medicine
Synopsis
- What is Epigenetic Reprogramming of Aging (ERA) and why it is a paradigm shift
- Why mRNAs are the solution for a safe epigenetic reprogramming
- How Turn is enabling the delivery of ERA mRNAs in vivo
12:15 pm Advancements in Senotherapeutics to Develop Novel Therapies
Synopsis
- Achieving precise targeting of senescent cells to de-risk therapies and prevent unwanted side effects
- Discussing strategies to overcome senescent cell heterogeneity to improve targeting of senescent cells
- Developing appropriate biomarkers for the type of senescent cells being targeted
- Beyond senolytics: other approaches to reduce cellular senescence
12:45 pm Lunch & Networking
1:45 pm Targeting Aging with Senolytic CAR T cells
Synopsis
- Building a case for CAR T therapies in regenerative medicine and age-related pathologies
- Developing persistent and lasting effects after single administration
2:15 pm Afternoon Break & Networking
Addressing the Challenges in Clinical Trial Design and Execution for Age-Related Therapeutics
3:15 pm Minimizing Risk in Regenerative Therapies
Synopsis
- Delivering partial reprogramming to reduce the risk of tumorigenicity
- Preventing off-target effects and ensuring expression is only seen in the organ of interest
- Tackling dosage and delivery challenges in regenerative therapies
3:45 pm Selecting the Appropriate Surrogate Endpoint for Aging
Synopsis
- Utilizing surrogate endpoints to streamline clinical trials and accelerate the de elopement of age-related therapeutics
- Selecting the correct surrogate endpoint to set up a therapy for being used off-label
- Ensuring reliability and validity of surrogate endpoints to ensure valid data